Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
Envelope protein-targeted vaccines for flaviviruses are restricted by issues of antibody-dependent enhancement (ADE) of infections. Nonstructural protein 1 (NS1) offers another vaccine goal that avoids this threat since this protein is absent from the virion. Past its intracellular function in virus replication, extracellular types of NS1 perform in immune modulation and are acknowledged by host-derived antibodies. The rational design of...